The cellular processes underlying the formation of memory share many similarities with the immune system, as both are intricate networks that affect, and are affected, by the body via multiple ‘modes’ of operation. Indeed, the two systems are functionally integrated, with the brain’s immune system helping to regulate synaptic plasticity and memory. At the molecular level, memory and the immune system are functionally integrated by non-coding RNAs (ncRNAs), which have recently emerged as key regulators of cellular activity throughout the phases of memory and in the adaptive immune system. Given that individual ncRNAs can function either independently or cooperatively between the two systems, these molecules are key targets in understanding the cellular processes underlying memory and the immune system. The Vault ncRNA family is comprised of small ncRNAs (sncRNAs) that may functionally intersect memory and the immune system. We have found that the Vault RNA, Vaultrc5, is heavily upregulated at the synapse, and that when knocked down attenuates fear extinction. Additionally, we have been able to confirm that the Vault carries cargo, which is modified following Vaultrc5 knockdown. Further, other studies have shown that Vault RNA are found in extracellular vesicles, suggesting a role in intercellular communication. Given the key role of ncRNA in the immune system, and our unpublished data, this investigation will provide key insights into how memory and the immune system work together.