The landscape of Nanoparticle generation is changing rapidly. Interestingly most commercial offerings are not particularly novel, some are blatant ‘me-too’s’ and frankly most struggle with scale. To understand the future a dive into history helps. Let’s discuss several modalities of nanoparticle generation such as T-tube mixers, microfluidics, confined injection mixers, and advanced cross flow technologies to understand why they work or not.